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A total of 3 % of Energetic compound is excreted in urine as unchanged Lively compound. Tapentadol is In addition metabolised to N-desmethyl tapentadol (13 %) by CYP2C9 and CYP2C19 also to hydroxy tapentadol (2 %) by CYP2D6, that happen to be further more metabolised by conjugation. Therefore, Energetic compound metabolism mediated by cytochrome P4